Efficacy observation and evaluation of cefepime in the treatment of bacterial infection of gynecology
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摘要: 目的：评价头孢吡肟治疗妇科细菌性感染的疗效及安全性。方法将235例妇科细菌性感染患者随机分为试验组118例，对照组117例，按照卫生部颁发的《抗菌药物临床研究指导原则》进行临床观察。对照组给予头孢他啶2．0g加入0．9％氯化钠注射液250mL中静脉滴注，2次/d；试验组给予头孢吡肟2．0g加入0．9％氯化钠注射液250mL中静脉滴注，2次/d。2组疗程均为7～14 d。观察比较2组疗效及安全性。结果试验组与对照组痊愈率分别为50．85％、37．61％；有效率分别为92．37％、79．49％；细菌清除率分别为90．83％、75．47％。2组比较差异均有统计学意义（P ＜0．01），临床研究中未发现试验药物的严重不良反应。结论头孢吡肟治疗妇科细菌性感染安全、有效、疗效优于头孢他啶。Abstract: Objective To evaluate the efficacy and safety of cefepime in the treatment of bacterial infection of gynecology.Methods 235 bacterial infection patients were randomly divided into test group (n =118)and control group (n =117).The clinical observation was done according to Guidelines for Clinical Research of Antibiotics issued by Ministry of Health of the People′s Repub-lic of China.The control group was treated with intravenous injection of ceftazidime for 2.0 g added into 250 mL of Sodium Chloride Injection (concentration of 0.9%)twice a day,while the test group was treated with cefepime 2.0 g added into 250 mL of Sodium Chloride Injection(concentra-tion of 0.9%)twice a day.The treatment periods for the two groups were both 7 to 14 days.The efficacy and safety were observed and compared.Results The clinical cure rates of the test group and the control group were 50.85% and 37.61% respectively;The effective rates were 92.37%and 79.49% respectively,and the clearance rates of bacteria were 90.83% and 75.47% respective-ly.There was significant difference between the two groups (P <0.01).No serious adverse reac-tion was found during the clinical research.Conclusion Cefepime is more safety,effective,and has better clinical efficacy than ceftazidime in the treatment of bacterial infection of gynecology.
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Keywords:
- cefepime /
- bacterial infection of gynecology /
- efficacy /
- safety
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