老年肝细胞癌患者手术前后 HBV-DNA及肝功能变化的研究

吴朝霞

吴朝霞. 老年肝细胞癌患者手术前后 HBV-DNA及肝功能变化的研究[J]. 实用临床医药杂志, 2014, (13): 41-43. DOI: 10.7619/jcmp.201413013
引用本文: 吴朝霞. 老年肝细胞癌患者手术前后 HBV-DNA及肝功能变化的研究[J]. 实用临床医药杂志, 2014, (13): 41-43. DOI: 10.7619/jcmp.201413013
WU Zhaoxia. Change of HBV-DNA and liver function before and after surgery in patients with hepatic cellular cancer[J]. Journal of Clinical Medicine in Practice, 2014, (13): 41-43. DOI: 10.7619/jcmp.201413013
Citation: WU Zhaoxia. Change of HBV-DNA and liver function before and after surgery in patients with hepatic cellular cancer[J]. Journal of Clinical Medicine in Practice, 2014, (13): 41-43. DOI: 10.7619/jcmp.201413013

老年肝细胞癌患者手术前后 HBV-DNA及肝功能变化的研究

详细信息
  • 中图分类号: R735.7

Change of HBV-DNA and liver function before and after surgery in patients with hepatic cellular cancer

  • 摘要: 目的:研究老年肝细胞癌患者行肝癌根治术前后 HBV-DNA 载量及肝功能变化,并探讨 HBV-DNA 载量对于术后患者肝功能恢复状况的预测价值。方法分析2011年1月-2013年1月在本院接受住院手术治疗的肝细胞癌患者的临床资料,根据术前 HBV-DNA 载量分为阴性组、低复制组、中复制组和高复制组四组。比较4组患者术前术后的 HBV-DNA 载量及肝功能变化。结果本研究共入组患者65例,其中阴性组10例,低复制组27例,中复制组18例和高复制组10例。手术治疗1周后,阴性组和低复制组患者的HBV-DNA载量有所下降,而中、高复制组载量有所升高,但差异均无统计学意义(P均>0.05);4组患者术后第一天的 ALT、AST 水平均显著高于术前水平(P 均<0.01),Alb 水平有所下降,差异有统计学意义(P 均<0.05)。TBIL 术前术后差值并无统计学意义(P 均>0.05);术前 HBV-DNA 载量对术后患者肝功能恢复时间的预测价值曲线下面积为0.901,敏感性为77.65%,特异性为87.24%。结论HCC 患者手术后的 HBV 的复制仍然很活跃,术前 HBV-DNA载量对于术后患者肝功能恢复时间有着一定的预测价值。
    Abstract: Objective To analyze the change of HBV-DNA and liver function before and af-ter surgery in patients with hepatic cellular cancer.Methods Clinical materials of patients with were retrospectively analyzed.They were divided into 4 groups according to the level of HBV-DNA before surgery.Results The liver function of patients decreased significantly after surgery.The.There was no significant difference of TBIL before and after operation.ROC of preoperative HBV-DNA value in prediction of recovery time of postoperative liver function was 0.901,sensitivity was 77.65%,and specificity was 87.24%.Conclusion Level of HBV-DNA shows a significant meaning in the predic-tion of the recovery time of liver function.
  • Kocabayoglu P, Friedman S L. Cellular basis of hepatic fibro-sis and its role in inflammation and cancer [J]. Front Biosci (Schol Ed), 2013.217.
    Zhao J, Zhao Y, Wang H. Association between meta-bolic abnormalities and HBV related hepatocelluar carcinoma in Chinese:a cross-sectional study [J]. NUTRITION JOURNAL, 2011.49.
    Woo S M, Park J W, Lee W J. Clinical and virological responses to clevudine therapy of hepatocelluar carcinoma pa-tients with chronic hepatitis B [J]. Gut Liver, 2011(1):82.
    Ottone A, Bellini E, Ferrero A. A case of long-term survival after repeated response to oxaliplatin-based chemo-therapy and repeated thermoablation of liver metastases from colorectal cancer.Should we introduce the concept of oxali-platin-resistant tumors [J]. TUMORI, 2013(3):91e.
    Park S G, Chung C H, Park C Y. Colon perforat ion during sorafenib therapy for advanced hepatocelluar carcinoma.A case report [J]. TUMORI, 2011(6):794.
    Ryu H S, Lee K, Shin E. Comparative analysis of im-munohistochemical markers for differential diagnosis of hepa-tocelluar carcinoma and cholangiocarcinoma [J]. TUMORI, 2012(4):478.
    Xu J, Liu C, Zhou L. Distinctions between clinicopath-ological factors and prognosis of alpha-fetoprotein negative and positive hepatocelluar carcinoma patients [J]. Asian Pacific Journal of Cancer Prev, 2012(2):559.
    Li M, Gerber D A, Koruda M. Hepatocelluar carcino-ma associated with attenuated familial adenomatous polyposis:a case report and review of the literature [J]. Clin Colorectal Cancer, 2012(1):77.
    Huo L, Dang Y, Feng R. Hepatocelluar carcinoma in an accessory lobe of the liver revealed by 11C-acetate PET with a negative finding on FDG imaging [J]. CLINICAL NUCLEAR MEDICINE, 2012(4):393.
    Yao Y, Li J, Lu Z. Proteomic analysis of the interleu-kin-4 (IL-4)response in hepatitis B virus-positive human hepatocelluar carcinoma cell line HepG2.2.15 [J]. Electro-phoresis, 2011, (15):2004.
    Sheng-Long Y. Asia-pacific primary liver cancer expert meet-ings [J]. Liver cancer, 2012(2):61.
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出版历程
  • 发布日期:  2014-09-10

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