替吉奥胶囊联合奥沙利铂治疗晚期胃癌的疗效分析

冯志平; 沈丽达; 李云霞; 邓明佳; 谢琳

doi:10.7619/jcmp.201307013

替吉奥胶囊联合奥沙利铂治疗晚期胃癌的疗效分析

云南省肿瘤医院肿瘤内一科,云南昆明,650118

基金项目: 中国高校医学期刊临床专项资金

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中图分类号: R735.2
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- 发布日期: 2013-06-12

Analysis of therapeutic effects of S-1 capsules combined with oxaliplatin for advanced gastric cancer

摘要

摘要: 目的观察替吉奥(S-1)胶囊联合奥沙利铂治疗晚期胃癌的近期疗效及毒副反应.方法将62例具有可测量病灶的晚期胃癌患者随机分为2组.S-1组(n=30)根据体表面积确定S-1与奥沙利铂的初始剂量；FOLFOX7组(n=32)使用5-氟尿嘧啶(5-Fu)、亚叶酸钙(CF)和奥沙利铂,2组均于2个周期后评估疗效.结果 S-1组完全缓解(CR)1例,部分缓解(PR)12例,有效率为43.3％；FOLFOX7组CR1例,PR 11例,有效率为37.5％,2组有效率比较无统计学意义.2组患者不良反应主要为恶心、呕吐、骨髓抑制、周围神经毒性及肝肾损害,2组不良反应无显著差异.结论 S-1胶囊联合奥沙利铂治疗进展期胃癌与FOLFOX7疗效相当,但不良反应较轻,耐受性较好.
- 晚期胃癌 /
- 替吉奥 /
- 奥沙利铂 /
- 毒副反应

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参考文献(15)

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替吉奥胶囊联合奥沙利铂治疗晚期胃癌的疗效分析

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Analysis of therapeutic effects of S-1 capsules combined with oxaliplatin for advanced gastric cancer

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